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Graphical contents list • MISCELLANEOUS PDF (297 K) | |||
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Bioorganic & Medicinal Chemistry Letters Symposia-in-Print • LITERATURE PDF (71 K) | |||
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Neuronal nicotinic receptors and ligands • EDITORIAL SummaryPlus | Full Text + Links | PDF (61 K) | |||
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Potential applications of nicotinic ligands in the laboratory and clinic • SHORT COMMUNICATION J. A. Dani , M. De Biasi , Y. Liang , J. Peterson , L. Zhang , T. Zhang and F. M. Zhou SummaryPlus | Full Text + Links | PDF (134 K) | |||
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 4 2 nACh Receptor pharmacophore models • SHORT COMMUNICATIONRichard A. Glennon and Ma SummaryPlus | Full Text + Links | PDF (191 K) | |||
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Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells • SHORT COMMUNICATION Yingxian Xiao , Maryna Baydyuk , Haizhu (Pearl) Wang , Heather E. Davis and Kenneth J. Kellar SummaryPlus | Full Text + Links | PDF (139 K) | |||
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Activity of 7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes • SHORT COMMUNICATION R. L. Papke , Julia K. Porter Papke and G. M. Rose SummaryPlus | Full Text + Links | PDF (183 K) | |||
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Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors • SHORT COMMUNICATION Zhi-Liang Wei , Yingxian Xiao , Kenneth J. Kellar and Alan P. Kozikowski SummaryPlus | Full Text + Links | PDF (153 K) | |||
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Neuronal nicotinic receptors and epilepsy, from genes to possible therapeutic compounds • SHORT COMMUNICATION Ronald C. Hogg and Daniel Bertrand SummaryPlus | Full Text + Links | PDF (156 K) | |||
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Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents • SHORT COMMUNICATION Linda P. Dwoskin , Sangeetha P. Sumithran , Jun Zhu , A. Gabriela Deaciuc , Joshua T. Ayers and Peter A. Crooks SummaryPlus | Full Text + Links | PDF (155 K) | |||
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Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release • SHORT COMMUNICATION Peter A. Crooks , Joshua T. Ayers , Rui Xu , Sangeetha P. Sumithran , Vladimir P. Grinevich , Lincoln H. Wilkins , A. Gabriela Deaciuc , David D. Allen and Linda P. Dwoskin SummaryPlus | Full Text + Links | PDF (204 K) | |||
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Contemporary paradigms for cholinergic ligand design guided by biological structure • SHORT COMMUNICATION Palmer Taylor , Scott B. Hansen , Todd T. Talley , Ryan E. Hibbs and Zoran Radi SummaryPlus | Full Text + Links | PDF (109 K) | |||
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Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation • SHORT COMMUNICATION Luis E. F. Almeida , Edna F. R. Pereira , Adriana L. Camara , Alfred Maelicke and Edson X. Albuquerque SummaryPlus | Full Text + Links | PDF (338 K) | |||
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Epibatidine structure–activity relationships • SHORT COMMUNICATION F. Ivy Carroll SummaryPlus | Full Text + Links | PDF (357 K) | |||
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Activation and desensitization of heteromeric neuronal nicotinic receptors: implications for non-synaptic transmission • SHORT COMMUNICATION Robin A. J. Lester SummaryPlus | Full Text + Links | PDF (220 K) | |||
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Nickle(II) and cobalt(II) complexes of hydroxyl-substituted triazamacrocyclic ligand as potential antitumor agents • SHORT COMMUNICATION Feng Liang , Ping Wang , Xiang Zhou , Tao Li , Zhaoyang Li , Huakuan Lin , Dongzhao Gao , Congyi Zheng and Chengtai Wu SummaryPlus | Full Text + Links | PDF (231 K) | |||
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Synthesis and evaluation of lasonolide A analogues • SHORT COMMUNICATION Jung Min Joo , Hyo Shin Kwak , Jin Hyun Park , Ho Young Song and Eun Lee SummaryPlus | Full Text + Links | PDF (192 K) | |||
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Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone–dipeptide scaffold • SHORT COMMUNICATION Manish Tandon , David L. Coffen , Paul Gallant , Dennis Keith and Mark A. Ashwell SummaryPlus | Full Text + Links | PDF (153 K) | |||
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N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the 2 subunit of voltage gated calcium channels • SHORT COMMUNICATIONJongwon Lim , Nicholas Stock , Richard Pracitto , Julia K. Boueres , Benito Munoz , Ashok Chaudhary , Angelina M. Santini , Karia Orr , Hervé Schaffhauser , Robert E. Bezverkov et al. SummaryPlus | Full Text + Links | PDF (184 K) | |||
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Hydroxytriamides as potent  -secretase inhibitors • SHORT COMMUNICATIONC. V. C. Prasad , Jeffrey W. Noonan , Charles P. Sloan , Wai Lau , Shikha Vig , Michael F. Parker , David W. Smith , Steven B. Hansel , Craig T. Polson , Donna M. Barten et al. SummaryPlus | Full Text + Links | PDF (221 K) | |||
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Evans Blue and other dyes as protein tyrosine phosphatase inhibitors • SHORT COMMUNICATION Suja Shrestha , Yi Sup Shim , Ki Chul Kim , Keun-Hyeung Lee and Hyeongjin Cho SummaryPlus | Full Text + Links | PDF (168 K) | |||
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N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography • SHORT COMMUNICATION Tatsuya Kikuchi , Ming-Rong Zhang , Nobuo Ikota , Kiyoshi Fukushi , Toshimitsu Okamura , Kazutoshi Suzuki , Yasushi Arano and Toshiaki Irie SummaryPlus | Full Text + Links | PDF (191 K) | |||
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Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors • SHORT COMMUNICATION Giancarlo Cravotto , Gianni Balliano , Bruna Robaldo , Simonetta Oliaro-Bosso , Stefano Chimichi and Marco Boccalini SummaryPlus | Full Text + Links | PDF (170 K) | |||
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Probing pockets S2–S4′ of the -secretase active site with (hydroxyethyl)urea peptidomimetics • SHORT COMMUNICATION William P. Esler , Chittaranjan Das and Michael S. Wolfe SummaryPlus | Full Text + Links | PDF (169 K) | |||
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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants • SHORT COMMUNICATION Robert B. Perni , Luc J. Farmer , Kevin M. Cottrell , John J. Court , Lawrence F. Courtney , David D. Deininger , Cynthia A. Gates , Scott L. Harbeson , Joseph L. Kim , Chao Lin et al. SummaryPlus | Full Text + Links | PDF (236 K) | |||
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Carnosic acid, a new class of lipid absorption inhibitor from sage • SHORT COMMUNICATION Kiyofumi Ninomiya , Hisashi Matsuda , Hiroshi Shimoda , Norihisa Nishida , Naoki Kasajima , Tomoe Yoshino , Toshio Morikawa and Masayuki Yoshikawa SummaryPlus | Full Text + Links | PDF (175 K) | |||
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De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library • SHORT COMMUNICATION Richard A. Houghten , Colette T. Dooley and Jon R. Appel SummaryPlus | Full Text + Links | PDF (240 K) | |||
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Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors • SHORT COMMUNICATION Md. Jashim Uddin , P. N. Praveen Rao and Edward E. Knaus SummaryPlus | Full Text + Links | PDF (224 K) | |||
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Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor • SHORT COMMUNICATION Afshin Zarghi , P. N. Praveen Rao and Edward E. Knaus SummaryPlus | Full Text + Links | PDF (192 K) | |||
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1,2,3,4-Tetrahydrocarbazoles as 5-HT6 serotonin receptor ligands • SHORT COMMUNICATION Jean Chang-Fong , Jagadeesh B. Rangisetty , Ma SummaryPlus | Full Text + Links | PDF (163 K) | |||
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Proteasome inhibitors: synthesis and activity of arecoline oxide tripeptide derivatives • SHORT COMMUNICATION Mauro Marastoni , John McDonald , Anna Baldisserotto , Alessandro Canella , Carmela De Risi , Gian Piero Pollini and Roberto Tomatis SummaryPlus | Full Text + Links | PDF (147 K) | |||
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Modified norcantharidins: synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity • SHORT COMMUNICATION Matthew E. Hart , A. Richard Chamberlin , Cecilia Walkom , Jennette A. Sakoff and Adam McCluskey SummaryPlus | Full Text + Links | PDF (174 K) | |||
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Structure–activity relationships of untenone A and its derivatives for inhibition of DNA polymerases • SHORT COMMUNICATION Fumiyo Saito , Ryo Takeuchi , Tomoyuki Kamino , Kouji Kuramochi , Fumio Sugawara , Kengo Sakaguchi and Susumu Kobayashi SummaryPlus | Full Text + Links | PDF (153 K) | |||
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Sulfonyl-phenyl-ureido benzamidines: a novel structural class of potent antimalarial agents • SHORT COMMUNICATION Johann Leban , Stefano Pegoraro , Matthias Dormeyer , Michael Lanzer , Andrea Aschenbrenner and Bernd Kramer SummaryPlus | Full Text + Links | PDF (196 K) | |||
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Parallel synthesis of DAPT derivatives and their -secretase-inhibitory activity • SHORT COMMUNICATION Toshiyuki Kan , Yusuke Tominari , Kentaro Rikimaru , Yuichi Morohashi , Hideaki Natsugari , Taisuke Tomita , Takeshi Iwatsubo and Tohru Fukuyama SummaryPlus | Full Text + Links | PDF (177 K) | |||
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Facile synthesis of metal-chelating peptides on chip for protein array • SHORT COMMUNICATION Ching-Wen Cheng , Kuo-Chin Lin , Fu-Ming Pan , Supachok Sinchaikul , Chi-Huey Wong , Wei-Chih Su , Ching-Hsiang Hsu and Shui-Tein Chen SummaryPlus | Full Text + Links | PDF (261 K) | |||
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(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[ and ]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons • SHORT COMMUNICATION Yong-Jin Wu , Christopher G. Boissard , Jie Chen , William Fitzpatrick , Qi Gao , Valentin K. Gribkoff , David G. Harden , Huan He , Ronald J. Knox , Joanne Natale et al. SummaryPlus | Full Text + Links | PDF (229 K) | |||
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Discovery and optimization of 2-aryl oxazolo-pyrimidines as adenosine kinase inhibitors using liquid phase parallel synthesis • SHORT COMMUNICATION M. Bauser , G. Delapierre , M. Hauswald , T. Flessner , D. D'Urso , A. Hermann , B. Beyreuther , J. De Vry , P. Spreyer , E. Reissmüller and H. Meier SummaryPlus | Full Text + Links | PDF (196 K) | |||
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Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives • SHORT COMMUNICATION Mankil Jung , Kyunghoon Lee , Hochul Jung , Howard Kendrick , Vanessa Yardley and Simon L. Croft SummaryPlus | Full Text + Links | PDF (144 K) | |||
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Editorial board • MISCELLANEOUS PDF (57 K) | |||
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Contributors to this issue • MISCELLANEOUS PDF (52 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (109 K) | |||
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